Myasthenia gravis in teens

Juvenile Myasthenia Gravis JMG is a rare disorder, defined as myasthenia gravis in children younger than 18 years of age. While clinical phenotypes are similar to adults, there are a number of caveats that influence management: broader differential diagnoses; higher rates of spontaneous remission; and the need to initiate appropriate treatment early, to avoid the long-term physical and psychosocial morbidity. Current practice is taken from treatment guidelines for adult MG or individual experience, with considerable variability seen across centers. We discuss our approach to treating JMG, in a large specialist JMG service, and review currently available evidence and highlight potential areas for future research. First-line treatment of generalized JMG is symptomatic management with pyridostigmine, but early use of immunosuppression, where good control is not achieved is important.
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08.02.2021
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Juvenile Myasthenia Gravis

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Myasthenia Gravis (MG) in Children - Health Encyclopedia - University of Rochester Medical Center

Myasthenia gravis or myasthenia is a condition that causes weakness in the voluntary muscles the muscles we can control. The weakness can come and go, and vary from mild to severe. In children, the condition is called juvenile myasthenia gravis or JMG. Myasthenia gravis is usually either ocular eye myasthenia or generalized myasthenia gravis. Ocular myasthenia gravis can spread and become generalized myasthenia gravis.
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Myasthenia gravis MG is an autoimmune disease in which antibodies are directed against the postsynaptic membrane of the neuromuscular junction, resulting in muscle weakness and fatigability. Juvenile myasthenia gravis JMG is a rare condition of childhood and has many clinical features that are distinct from adult MG. Prepubertal children in particular have a higher prevalence of isolated ocular symptoms, lower frequency of acetylcholine receptor antibodies, and a higher probability of achieving remission. Diagnosis in young children can be complicated by the need to differentiate from congenital myasthenic syndromes, which do not have an autoimmune basis.
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Myasthenia gravis MG is a disorder that causes weakness in muscles around the body. This happens because antibodies destroy some of the places where nerves and muscles meet neuromuscular connections. MG affects the voluntary muscles of the body. It mostly affects the eyes, mouth, throat, arms, and legs.
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